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31.
Ellen Hollands Steffensen Anne Skakkebæk Kasper Gadsbøll Olav Bjørn Petersen Thomas Westover Heather Strange The NIPT-SCA-map Study Group Ida Vogel 《黑龙江环境通报》2023,43(2):144-155
Objective
To examine the extent to which sex chromosomes are included in current noninvasive prenatal testing (NIPT) and the reporting practices with respect to fetal chromosomal sex and sex chromosome aberrations (SCAs), in addition to an update on the general implementation of NIPT.Method
A questionnaire addressing the research objectives was distributed by email to fetal medicine and clinical genetics experts in Asia, Australia, Europe and the USA.Results
Guidelines on NIPT are available in the majority of the included countries. Not all existing guidelines address reporting of fetal chromosomal sex and SCAs. In most settings, NIPT frequently includes sex chromosomes (five Australian states, China, Hong Kong, Israel, Singapore, Thailand, USA and 23 of 31 European countries). This occurs most often by default or when parents wish to know fetal sex. In most settings, a potential SCA is reported by stating the risk hereof as “low” or “high” and/or by naming the SCA. Less than 50% of all pregnant women receive NIPT according to respondents from three Australian states, China, Israel, Singapore, Thailand and 24 of 31 European countries. However, this percentage, the genomic coverage of NIPT and its application as primary or secondary screening vary by setting.Conclusion
In most of the studied countries/states, NIPT commonly includes sex chromosomes. The reporting practices concerning fetal chromosomal sex and SCAs are diverse and most commonly not addressed by guidelines. In general, NIPT is variably implemented across countries/states. 相似文献32.
Bengt Lundén 《Ambio-人类环境杂志》2003,32(5):374-377
在瑞典斯卡格拉克海峡沿岸,大叶藻(Zostera
marina)是一种生长在浅水软海底上的优势显花植物.大叶藻场是许多甲壳动物和鱼类,不管是洄游种或是稳定种的重要群落生境.在20世纪80年代期间,作为海岸带管理的基础,对瑞典西海岸有大叶藻生长的沿岸浅水区的资源进行了调查.在这次研究中我们再次考察了斯卡格拉克海峡200km沿岸的5个沿海地区中的2000hm2大叶藻场.资源调查的方法(水下测量镜)与80年代的一样,但通过使用全球定位系统(GPS)增加了绘图的精确度.这次研究的结果表明,在10~15年的时间里,大叶藻的区域延伸面积减少了58%,且地区变化很大.大叶藻的减少主要限于大叶藻场的浅水部分.本文探讨了原因和生态后果. 相似文献
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35.
Pihl Karlsson G Akselsson C Hellsten S Karlsson PE 《Environmental pollution (Barking, Essex : 1987)》2011,159(12):3571-3582
Changes in sulphur and nitrogen pollution in Swedish forests have been assessed in relation to European emission reductions, based on measurements in the Swedish Throughfall Monitoring Network. Measurements were analysed over 20 years with a focus on the 12-year period 1996 to 2008. Air concentrations of SO2 and NO2, have decreased. The SO4-deposition has decreased in parallel with the European emission reductions. Soil water SO4-concentrations have decreased at most sites but the pH, ANC and inorganic Al-concentrations indicated acidification recovery only at some of the sites. No changes in the bulk deposition of inorganic nitrogen could be demonstrated. Elevated NO3-concentrations in the soil water occurred at irregular occasions at some southern sites. Despite considerable air pollution emission reductions in Europe, acidification recovery in Swedish forests soils is slow. Nitrogen deposition to Swedish forests continues at elevated levels that may lead to leaching of nitrate to surface waters. 相似文献
36.
Kasper Lundtorp Dorthe L. Jensen Thomas H. Christensen 《Journal of the Air & Waste Management Association (1995)》2013,63(6):722-731
Abstract A stabilization method for air pollution control (APC) residues from municipal solid waste incineration (MSWI) involving mixing of the residue with water and FeSO4 has been demonstrated on a semi-industrial scale on three types of APC residues: a semidry (SD) APC residue, a fly ash (FA), and an FA mixed with sludge (FAS) from a wet flue gas cleaning system. The process was performed in batches of 165-175 kg residue. It generates a wastewater that is highly saline but has a low content of heavy metals such as Cd, Cr, and Pb. The stabilized and raw residues have been subject to a range of leaching tests: the batch leaching test, the pH-static leaching test, the availability test, and the column test. These tests showed that the stabilized residues have remarkably improved leaching properties, especially with respect to Pb but also with respect to Cd, Cu, and Zn. The release of Pb was reduced by a factor of 250-36,000. 相似文献
37.
Solbu K Hersson M Thorud S Lundanes E Nilsen T Synnes O Ellingsen D Molander P 《Journal of environmental monitoring : JEM》2010,12(5):1195-1202
Suddenly occurring and time limited chemical exposures caused by unintended incidents might pose a threat to many workers at various work sites. Monitoring of exposure during such occasional incidents is challenging. In this study a compact, low-weight and personal semi-automatic pumped unit for sampling of organic vapor phase compounds from occupational air during sporadic and suddenly occurring incidents has been developed, providing simple activation by the worker potentially subjected to the sudden occurring exposures when a trained occupational hygienist is not available. The sampler encompasses a tube (glass or stainless steel) containing an adsorbent material in combination with a small membrane pump, where the adsorbent is capped at both ends by gas tight solenoid valves. The sampler is operated by a conventional 9 V battery which tolerates long storage time (at least one year), and is activated by pulling a pin followed by automatic operation and subsequent closing of valves, prior to shipping to a laboratory. The adjustable sampling air flow rate and the sampling time are pre-programmed with a standard setting of 200 mL min(-1) and 30 min, respectively. The average airflow in the time interval 25-30 min compared to average airflow in the interval 2-7 min was 92-95% (n = 6), while the flow rate between-assay precisions (RSD) for six different samplers on three days each were in the range 0.5-3.7%. Incident sampler recoveries of VOCs from a generated VOC atmosphere relative to a validated standard method were between 95 and 102% (+/-4-5%). The valves that seal the sampler adsorbent during storage have been shown to prevent an external VOC atmosphere (500 mg m(-3)) to enter the adsorbent tube, in addition to that the sampler adsorbent is storable for at least one month due to absence of ingress of contaminants from internal parts. The sampler was also suitable for trapping of semi-volatile organophosphates. 相似文献
38.
In demersal fish species with a pelagic larval stage, settlement patterns may be a consequence of variations in larval supply, habitat selection at settlement, and processes acting between the time of settlement and the time of benthic sampling. This study describes temporal (1994-1998) and spatial variation in plaice (Pleuronectes platessa L.) settlement densities in four semi-isolated nursery areas with similar habitat characteristics, in the non-tidal Gullmarsfjord on the west coast of Sweden. Juvenile abundance varied by a factor of ten, both among years and among nursery grounds. For the 3 years when larval sampling was undertaken (1994-1996) and all nursery areas, there was a significant positive relationship between larval supply and juvenile abundance (linear regression: r2=0.45, n=24, P<0.001). On the southern side of the fjord, a significant positive relationship between larval and juvenile abundance was found in one area (r2=0.62, n=6, P<0.05). The absolute mortality rate of plaice after settlement was related to the initial settlement density (r2=0.95, n=20, P<0.001), and to the abundance of predatory shrimps Crangon crangon (r2=0.44, n=20, P<0.01). Plaice otoliths were found in 6% of the shrimp stomachs analysed from an area with high density (13.3 m-2) of newly settled plaice. The present study suggests that the density of juvenile plaice was limited by larval supply to the nursery grounds. Consistency in the relative abundance of juveniles among nursery grounds between years also suggested that some nursery areas may be in the settlement shadow of others. The irregular nature of the coastline in combination with larval depletion could thereby cause small-scale (103-104 m) variation in settlement densities of the same order of magnitude as the inter-annual variability in recruitment to individual nursery grounds. 相似文献
39.
Along the Swedish Skagerrak coast eelgrass (Zostera marina) is a dominant phanerogam on shallow soft bottoms. Eelgrass meadows are important biotopes for many crustacean and fish species being either migratory or stationary. During the 1980s, inventories of the shallow coastal areas with eelgrass have been carried out along the Swedish west coast as a basis for coastal zone management. In the present study we revisited 2000 ha of eelgrass meadows in 5 coastal regions along 200 km of the Skagerrak coast. The inventory was made with the same methods (aquascope) as during the 1980s, but increasing the mapping accuracy by using a Global Positioning System (GPS). The results from this study show that the areal extension of Zostera marina has decreased 58% in 10-15 years with great regional variations. The decline was mainly restricted to the shallow parts of the meadow. The causes and ecological consequences are discussed. 相似文献
40.
Loretta Müller Pierre Comte Jan Czerwinski Markus Kasper Andreas C.R. Mayer Adrian Schmid 《毒物与环境化学》2013,95(1):164-180
The aim of this study was to compare the cytotoxicity and the (pro-)inflammatory responses of two-stroke (direct injection and carburetor technology) and four-stroke scooter and diesel car exhaust emissions on lung cells in vitro. This was analyzed by exposing a 3D in vitro model of the epithelial airway (consisting of human bronchial epithelial cells (cell line 16HBE14o?) combined with human whole blood monocyte-derived macrophages and dendritic cells) to physically characterized exhaust emissions. Biological endpoints of cytotoxicity (lactate dehydrogenase release), as well as pro-inflammatory cytokine (tumor necrosis factor (TNF)-α) and inflammatory chemokine (interleukin(IL)-8) stimulation were examined. Two-stroke direct injection scooter exhaust contained the highest particle number concentration and nitrogen oxides (NO x ) concentrations and the emissions from the two-stroke carburetor scooter contained the highest hydrocarbon and lowest NO x concentrations. The four-stroke scooter emitted the highest carbon monoxide concentration whereas the cars emitted the lowest. The combination of various technical optimizations for the two-stroke direct injection scooter (particle filter, oxidative catalyst, better oil and fuel) reduced the total emissions strongly and the TNF-α concentration significantly (p?0.05). The cytotoxicity and the IL-8 concentration showed strong tendencies to be reduced. The analysis of the emissions of all tested two-stroke, four-stroke scooters and diesel cars showed a strong association between the adverse effects and the particle number concentration. 相似文献